Lydia Chang, MD

Research Projects undertaken (in 2010-12)

Principal Investigator For Commercial Sponsored Second Line Study:
A Prospective Unmasked Randomised Evaluation of the IStent Inject (GTS400) versus Two Ocular Hypotensive Agents in Patients with Primary Open Angle Glaucoma.
NIHR CRN Study Reference: CCRN 288

Publications

Peer-reviewed publications:

• Ratnarajan G, Newsom W, French K, Kean J, Chang L, Parker M, Garway-Heath DF, Bourne RRA. The effect of changes in referral behaviour following NICE guideline publication on agreement of examination findings between professionals in an established glaucoma referral refinement pathway: The Health Innovation & Education Cluster (HIEC)   Glaucoma Pathways project. Accepted BJO 2012.
• Ratnarajan G, Newsom W, French K, Kean J, Chang L, Parker M, Garway-Heath D, Bourne R. Unnecessary referral rate and the risk stratification analysis of the Community and Hospital Allied Network Glaucoma Evaluation Scheme (CHANGES). Submitted for publication.
• Chang L, Ong EL, Bunce C, Brookes J, Papadopoulos M, Khaw PT. A Review of The Medical Treatment of Paediatric Glaucomas at Moorfields Eye Hospital Journal of Glaucoma 2012
  doi: 10.1097/IJG.0b013e31824d1e2f 
• Mandalos A, Bourne R, French K, Newsom W, Chang L. Shared care of patients with ocular hypertension in the Community and Hospital Allied Network Glaucoma Evaluation Scheme. Eye 2012 26, 564-567
  doi:10.1038/eye.2011.350.
• Bourne RR, French KA, Chang L, Borman AD, Hingorani M, Newson WD Can a community optometrist-based referral refinement scheme reduce false-positive glaucoma hospital referrals without compromising quality of care? The community and hospital allied network glaucoma evaluation scheme (CHANGES). Eye 2010: 24: 881.
• Chang L, Aung T, Low S, Wong TY, Khaw PT, Foster PJ. Is Measurement of Adult Height Useful in Screening for Primary Angle-Closure? Eye 2009: 23: 1775-1780.
• Chang L, Wong T, Ohbayashi M, Bunce C, Barton K, Ono S, Kahw PT. Increased Mast Cell Numbers in the Conjunctiva of Glaucoma Patients: a possible indicator of preoperative glaucoma surgery inflammation. Eye 2009: 23: 1859-1865.
• Low S, Harsum S, Chang L, Foster P, Khaw PT. Angle Closure. Ophthalmology 2008: 115(8): 1434-1435.
• Chang L, Thiagarajan M, Moseley M, Woodruff S, Bentley C, Khaw PT, Bloom P: Intraocular pressure outcome in primary 5FU phacotrabeculectomies compared to 5FU trabeculectomies.Journal of Glaucoma 2006: 15: 475-81.
• Chang L, Olver J: A useful augmented Lateral Tarsal Strip Tarsorrhaphy for Paralytic Ectropion. Ophthalmology 2006: 113; 84-91.
• Crowston JG, Chang L, Daniels JT, Khaw PT, Akbar AN. T lymphocyte mediated lysis of mitomycin C treated Tenon’s capsule fibroblasts. British Journal of Ophthalmology 2004; 88:399-405.
• Wong SC, Chang L, Lee N. Partial booking – is it flawed? Journal of Quality in Primary Care 2003: 11; 117-122.
• Chang L, Siriwardena D, Wilkins MR et al. In vivo Production of Interferon-beta by human tenon’s fibroblasts; a possible mediator for the development of chronic conjunctival inflammation. British Journal of Ophthalmology 2002: 86; 611-615.
• Crowston JG, Chang L, Constable PH, Daniels JT, Akbar AN, Khaw PT. Apoptosis Gene Expression and Death Receptor Signaling in Mitomycin-C treated Tenon’s Fibroblasts. Investigative Ophthalmology and Visual Science 2002: 43; 692-699.
• Sarangapani S, Chang L, Gregory-Evans KG. Cataract Surgery in Senior-Loken syndrome is beneficial despite severe retinopathy. Eye 2002: 16; 782-785.
• Chang L, Crowston JG, Sabin CA, Khaw PT, Akbar AN. Normal And Growth-Arrested Human Tenon's Fibroblasts Produce Interferon-Beta Which Prevents T Cell Apoptosis. Investigative Ophthalmology and Visual Science 2001: 42: 1531.
• Chang L, Crowston JG, Salmon M, Akbar AN, Khaw PT. Human Tenon’s Fibroblasts Mediate T cell Resistance to apoptosis – A possible mechanism for chronic inflammation & persistent wound healing. Investigative Ophthalmology and Visual Science 1999: S968.
• Chang L, Trendell-Smith N, Olver JM. Surgical management of an unexpected lacrimal mass. Eye 1999: 13; 262.

Chapters and Reviews:

• Chang L, Wilkins M, Brazier DJ. Chapter 18, Eyes. In Pathways in Surgery 3^rd edition, eds Hobsley M and Boulos PB. Arnold, London, 2002.
• Khaw PT, Chang L. Antifibrotic Agents in Glaucoma Surgery. In Textbook of Ophthalmology 2^nd edition, eds Duker D and Yanoff M. Mosby, St Louis, 2002.
• Chang L, Crowston JG, Akbar AN, Khaw PT. The Immune Response in Conjunctival Wound Healing after Glaucoma Surgery. Search on Glaucoma 2001: 3; 55-62. 
• Khaw PT, Chang L, Wong T, Mead A, Daniels JT, Cordeiro MF. Modulation of wound healing after glaucoma filtration surgery. Current Opinion in Ophthalmology 2001: 12; 143.
• Broadway D, Chang LP. Trabeculectomy, Risk Factors for Failure and the Preoperative State of the Conjunctiva. Journal of Glaucoma 2001: 10; 237-249.
• Chang L, Crowston JG, Cordeiro MF, Akbar AN, Khaw PT. The Immune Response In Conjunctival Wound healing. Survey of Ophthalmology 2000: 45; 49.
• Cordeiro MF, Chang L, Lim KS et al. Modulating Conjunctival Wound Healing. Eye 2000: 14; 536.
• Cordeiro MF, Siriwardena D, Chang L, Khaw PT. Wound Healing Modulation after Glaucoma Surgery. Current Opinion in Ophthalmology 2000: 11; 121.
• Cordeiro MF, Chang L, Khaw PT. The Healing of Ocular Tissues: The Basis of Successful Treatment of Ocular Disease. In Ophthalmology Clinics of North America: Ocular Surgery for the New Millenium, Part II. Ed. Spaeth GL. W.B. Saunders, Philadelphia, 2000: 13, 101-110.